HigBA toxin-antitoxin systems in Mycobacterium tuberculosis : stress-responsive regulation, persistence, and therapeutic perspectives

Q: What does this research mean for the field?

HigBA toxin-antitoxin systems mediate stress-responsive regulation and persistence in Mycobacterium tuberculosis, presenting potential targets for therapeutic intervention. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Zoozeal Thakur; Renu Chaudhary; Promod K. Mehta

doi:10.1080/14787210.2026.2719693

August 17, 2026Expert Review of Anti-infective Therapy

HigBA toxin-antitoxin systems in Mycobacterium tuberculosis : stress-responsive regulation, persistence, and therapeutic perspectives

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Key Points

To review the mechanisms of HigBA toxin-antitoxin systems in Mycobacterium tuberculosis, focusing on their stress-responsive regulation, role in bacterial persistence, and potential as therapeutic targets.
Synthesized molecular, biochemical, and genetic evidence on HigBA toxin-antitoxin module regulation in Mycobacterium tuberculosis.
Evaluated cellular responses to host-mediated stresses including nutrient starvation, hypoxia, and immune pressures.
HigBA systems function as key regulatory switches that halt bacterial growth to promote survival under host-derived physiological stress.
Activation of HigBA toxins facilitates the formation of persistent, drug-tolerant Mycobacterium tuberculosis subpopulations.
Disrupting HigBA interactions or artificially unleashing toxin activity represents a viable strategy for novel anti-tubercular drug development.

Implication

Review outlines stress-responsive HigBA toxin-antitoxin systems in Mycobacterium tuberculosis, highlighting their role in bacterial persistence and potential as therapeutic targets.

Abstract

Mycobacterium tuberculosis (Mtb) possesses a remarkable capacity to survive under prolonged host-imposed stress, a feature central to its persistence and pathogenic success. This ability of Mtb ...

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Cite This Study

Thakur et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5178a91293e6a1cc63b https://doi.org/10.1080/14787210.2026.2719693

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HigBA toxin-antitoxin systems in Mycobacterium tuberculosis : stress-responsive regulation, persistence, and therapeutic perspectives

Key Points

Implication

Abstract

Discussion

Cite This Study

HigBA toxin-antitoxin systems in Mycobacterium tuberculosis : stress-responsive regulation, persistence, and therapeutic perspectives

Key Points

Implication

Abstract

Discussion

Cite This Study

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