Acute "Graft-Versus-Host Disease" After Autografting for Chronic Granulocytic Leukemia in Transformation

Brief Reports1 February 1981Acute "Graft-Versus-Host Disease" After Autografting for Chronic Granulocytic Leukemia in TransformationSWEE LAY THEIN, B.M., B.S., JOHN M. GOLDMAN, B.M., DAVID A. G. GALTON, M.D.SWEE LAY THEIN, B.M., B.S., JOHN M. GOLDMAN, B.M., DAVID A. G. GALTON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-2-210 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFour cases of acute graft-versus-host disease have now been reported in patients who have received transplants of syngeneic bone marrow (1, 2). This phenomenon could be explained if graft-versus-host disease were due to an imbalance of lymphocyte subsets regardless of donor-recipient histocompatibility (3). We have recently seen a patient with chronic granulocytic leukemia in transformation who developed a syndrome resembling acutegraft-versus-host disease after autografting with stored buffy-coat leukocytes.A 23-year-old woman was found to have Philadelphia-chromosome-positive chronic granulocytic leukemia in August 1978. Peripheral blood cells were collected by leukapheresis and cryopreserved. She was treated with busulphan, and splenectomy was...References1. RAPPEPORTMIHMREINHERZLOPANSRIPARKMAN JMESR. Acute graft-versus-host disease in recipients of bone-marrow transplants from identical twin donors. Lancet. 1979;2:717-20 CrossrefMedlineGoogle Scholar2. GLUCKMANDEVERGIESOHIERSAURAT EAJJ. Graft-versus-host disease in recipients of syngeneic bone marrow. Lancet. 1980;1:253-4. Letter. MedlineGoogle Scholar3. REINHERZPARKMANRAPPEPORTROSENSCHLOSSMAN ERJFS. Aberrations of suppressor T cells in human graft-versus-host disease. N Engl J Med. 1979;300:1061-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hammersmith Hospital Royal Postgraduate Medical School London England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByReconstitution of self-tolerance after hematopoietic stem cell transplantationPossible Role of Engraftment Syndrome and Autologous Graft-Versus-Host Disease in Myelodysplastic Syndrome After Autologous Stem Cell Transplantations: Retrospective Analysis and Review of the LiteratureGastrointestinal Graft-versus-Host Disease in Recipients of Autologous Hematopoietic Stem Cells: Incidence, Risk Factors, and OutcomeModulation of Graft-versus-Host Disease: Role of Regulatory T LymphocytesCell populations and adhesion molecules expression in conjunctiva before and after bone marrow transplantationRisk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantationAutologous graft-versus-host disease in a porcine bone marrow transplant modelClinical course and predictive factors for cyclosporin-induced autologous graft-versus-host disease after autologous haematopoietic stem cell transplantationGlomerular and extraglomerular immune complex deposits in a bone marrow transplant recipientBile Duct Apoptosis and Cholestasis Resembling Acute Graft-Versus-Host Disease After Autologous Hematopoietic Cell TransplantationGuest Editorial: Autologous Graft-Versus-Host DiseaseACUTE INTESTINAL GRAFT-VERSUS-HOST DISEASE IN A SYNGENEIC BONE MARROW TRANSPLANT RECIPIENTImmunobiology and immunotherapeutic implication of syneneic/autologous graft-versus-host diseaseGraft-versus-host disease: implications from basic immunology for prophylaxis and treatmentRoquinimex-induced graft-versus-host reaction after autologous bone marrow transplantationGraft-versus-host disease after small bowel transplantation is associated with host colonic injuryNew and experimental therapies for treating graft-versus-host diseaseCurrent thoughts on the pathogenesis of graft versus host disease.Induction of Autologous Graft vs Host Disease: An Immunotherapeutic Approach to Eliminate Residual Leukemia After Autologous Bone Marrow TransplantationTransplants: A Confrontation of "Self" with "Non-Self"Cyclosporine-induced graft-versus-host disease after autologous bone marrow transplantation in hematological malignanciesA Clinical Review: Cutaneous Manifestations of Acute and Chronic Graft-versus-Host Disease Following Bone Marrow TransplantationBone marrow transplantation from mutantlpr/lpr mice. Functional abnormalities rather than alloantigenic differences appear to determine the development of a graft-vs. -host-like syndromeThe sweat gland in graft versus host diseaseGraft-Versus-Host DiseaseAcute graft-versus-host diseaseChronic graft-versus-host diseaseGraft-versus-host disease: an alternative hypothesisThe Pathogenesis of Graft-versus-Host Reaction in the Intrahepatic Bile DuctSyngeneic or autologous graft‐versus‐host diseaseGraft-versus-Host disease and other related diseases.Variation of treatment conditions alters the outcome of fetal liver transplantation in dogsHuman Marrow Transplantation: An Immunological PerspectiveModification of Emerging Repertoires by Immunosuppression in Immunodeficient Mice Results in AutoimmunityIntestinal and hepatic complications of human bone marrow transplantation. Part IThe fetal liver as an alternative stem cell source for hemolymphopoietic reconstitutionAcute and chronic graft-versus-host disease in manGraft-versus-Host-Reactions: The History that never Was, and the Way Things Happened to HappenGraft-versus-Host Reactions and DiseaseAcute and chronic graft versus host disease: Histopathological evidence for two distinct pathogenetic mechanismsAutologous marrow transplantation for patients with chronic myelogenous leukemia (CML) in blast crisisLethal GVHD Across Minor Histocompatibility Barriers: Nature of the Effector Cells and Role of the H-2 ComplexGraft-versus-host disease after treatment for chronic granulocytic leukaemia in transformation7 T cell subpopulations, monoclonal antibodies and their therapeutic applications 1 February 1981Volume 94, Issue 2Page: 210-211KeywordsBiopsyBone marrowDo not resuscitate ordersGranulocytesHematology and oncologyHemoglobinLymphocytesPlateletsSplenectomyWhite blood cells Issue Published: 1 February 1981 PDF DownloadLoading ...