Preclinical study demonstrates accelerated wound contraction and superior tissue remodeling in rats, suggesting potential regenerative applications for skin repair.
< 0.05) in wound contraction percentage was noticed in bUC-MSC and CM groups as early as day 2. The histo-morphological analysis revealed that in bUC-MSC and CM-treated groups enhanced monocytoid cell migration was noticed in inflammatory phase, exhibited superior collagen organization, and wound remodeling, which are critical for minimizing scar formation and ensuring functional recovery of the skin. The sustained effects observed after four weeks suggest that both bUC-MSCs and CM not only accelerate early healing processes but also contribute to the structural integrity and durability of the healed tissue. Overall, bUC-MSCs and its conditioned media represent a valuable addition to the toolkit of regenerative medicine.
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A et al. (2026) studied this question.
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