New Case of Acute Hepatitis Following the Consumption of Shou Wu Pian, a Chinese Herbal Product Derived from Polygonum multiflorum

Letters6 April 2004New Case of Acute Hepatitis Following the Consumption of Shou Wu Pian, a Chinese Herbal Product Derived from Polygonum multiflorumGabriela Mazzanti, PharmD, PhD, Lucia Battinelli, DSc, PhD, Claudia Daniele, PharmD, Claudio Maria Mastroianni, MD, PhD, Miriam Lichtner, MD, PhD, Simona Coletta, MD, PhD, and Sergio Costantini, DScGabriela Mazzanti, PharmD, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Lucia Battinelli, DSc, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Claudia Daniele, PharmDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Claudio Maria Mastroianni, MD, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Miriam Lichtner, MD, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Simona Coletta, MD, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., and Sergio Costantini, DScFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-7-200404060-00042-w3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Shou Wu Pian (Shenzou-Chinese Medical Centre, Amsterdam, the Netherlands) is a herbal product constituted by powdered root of Polygonum multiflorum Thunb (Polygonaceae). It is used in China as a tonic and antiaging remedy. In western countries, it is commonly found in herb shops and grocery stores in Chinatowns.Two patients with hepatotoxicity related to Shou Wu Pian have been described previously. The first one was a 31-year-old pregnant Chinese woman who had taken the product to treat hair loss (1). She had experienced a similar reaction with a preparation of the same herb about 2 years ...References1. But PP, Tomlinson B, Lee KL. Hepatitis related to the Chinese medicine Shou-wu-pian manufactured from Polygonum multiflorum. Vet Hum Toxicol. 1996;38:280-2. [PMID: 8829347] MedlineGoogle Scholar2. Park GJ, Mann SP, Ngu MC. Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum. J Gastroenterol Hepatol. 2001;16:115-7. [PMID: 11206309] CrossrefMedlineGoogle Scholar3. Guigen Y, Xiaoping S, Xinghang M, Mei P, Zhiling Q. Determination of anthraquinones in Polygonum multiflorum and its preparations by magnesium acetate methanol colorimetric method. Zhongcaoyao. 1983;14:255-8. Google Scholar4. European Pharmacopoeia 4th ed. European Directorate for the Quality of Medicines of the Council of Europe. Strasbourg, France 2002. Google Scholar5. Ciprotti M, Giordano R, Ciaralli L, Sepe A, Rossi P, Costantini S. Heavy metals in Ayurvedic preparations: analytical problems and toxicological aspects [Abstract]. 11th International Symposium on Trace Elements in Man and Animals (TEMA 11), Berkeley, California, 2−6 June 2002:74. Google Scholar6. de Witte P, Lemli L. The metabolism of anthranoid laxatives. Hepatogastroenterology. 1990;37:601-5. [PMID: 2289777] MedlineGoogle Scholar7. Tolman KG, Hammar S, Sannella JJ. Possible hepatotoxicity of Doxidan. Ann Intern Med. 1976;84:290-2. [PMID: 1259264] LinkGoogle Scholar8. Beuers U, Spengler U, Pape GR. Hepatitis after chronic abuse of senna [Letter]. Lancet. 1991;337:372-3. [PMID: 1671276] CrossrefMedlineGoogle Scholar9. Streicher E. Acute renal failure and jaundice following rhubarb leaf poisoning. Dtsch Med Wochenschr. 1964;89:2379-81. [PMID: 14225041] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University La Sapienza and Istituto Superiore di Sanità, Rome, Italy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatotoxic metabolites in Polygoni Multiflori Radix— Comparative toxicology in miceConcurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum : A case reportChanges of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides During Processing of Polygonum multiflorum ThunbCysteine-Based Protein Covalent Binding and Hepatotoxicity Induced by EmodinPolygonum Multiflorum (Ho-Shou-Wu)Causality imputation between herbal products and HILI: An algorithm evaluation in a systematic reviewHerb-Induced Liver Injury Related to Reynoutria multiflora (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic SpecificsScreening of Quality Markers During the Processing of Reynoutria multiflora Based on the UHPLC-Q-Exactive Plus Orbitrap MS/MS Metabolomic MethodThe toxicity and safety of Chinese medicine from the bench to the bedsideAdvances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-reviewProfile of herbal and dietary supplements induced liver injury in Latin America: A systematic review of published reportsIn vivo hepatotoxicity screening of different extracts, components, and constituents of Polygoni Multiflori Thunb. in zebrafish (Danio rerio) larvaeAdvances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorumA Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori RadixPolygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current ChallengesMetabolomics profiling of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata extracts using UPLC-Q/TOF-MSBioactivation of herbal constituents: mechanisms and toxicological relevanceInfluence Factors on the Hepatotoxicity of Polygoni Multiflori RadixHLA‐B*35:01 Allele Is a Potential Biomarker for Predicting Polygonum multiflorum–Induced Liver Injury in HumansHepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coinClinicopathological features of He Shou Wu - induced liver injury: This ancient anti-aging therapy is not liver-friendlyZhuang Gu Guan Jie Wan: Reasonable Application Can Alleviate the Liver Injury for Osteoarthritis TreatmentInterpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on RatsIn Vitro and in Vivo Studies of the Electrophilicity of Physcion and its Oxidative MetabolitesPolygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and HepatotoxicityComputational Toxicology for Traditional Chinese MedicineIdentification of urine tauro-β-muricholic acid as a promising biomarker in Polygoni Multiflori Radix-induced hepatotoxicity by targeted metabolomics of bile acidsIdiosyncratic drug-induced liver injury linked to Polygonum multiflorum: A case study by pharmacognosyDetection of Emodin Derived Glutathione Adduct in Normal Rats Administered with Large Dosage of Polygoni Multiflori RadixA New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory FactorRapid profiling and pharmacokinetic studies of major compounds in crude extract from Polygonum multiflorum by UHPLC-Q-TOF-MS and UPLC–MS/MSPolygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytesMetabolomic Study on Idiosyncratic Liver Injury Induced by Different Extracts of Polygonum multiflorum in Rats Integrated with Pattern Recognition and Enriched Pathways AnalysisTraditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAsHerbal Medicines: Boon or Bane for the Human Liver?PolygonaceaeHepatotoxicity of herbal and dietary supplements: an updateEffect of sample preparation on components and liver toxicity of Polygonum multiflorumHepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in ratsLiver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case SeriesEighteen cases of liver injury following ingestion of Polygonum multiflorumQualität und Sicherheit chinesischer Arzneidrogen in Deutschland - ein UpdateHepatotoxicity of Herbals and Dietary SupplementsQuality evaluation of Polygonum multiflorum in China based on HPLC analysis of hydrophilic bioactive compounds and chemometricsReview article: herbal and dietary supplement hepatotoxicityAdverse Drug Reactions and Pharmacovigilance of Herbal MedicinesHepatic injury due to drugs, herbal compounds, chemicals and toxinsDrug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum ThunbHepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori PraeparataHepatotoxicity or Hepatoprotection? Pattern Recognition for the Paradoxical Effect of the Chinese Herb Rheum palmatum L. in Treating Rat Liver InjuryPrescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002Comparison of raw and processed Radix Polygoni Multiflori (Heshouwu) by high performance liquid chromatography and mass spectrometryLiver Disease Caused by Anesthetics, Toxins, and Herbal PreparationsReactivation of Pulmonary Tuberculosis in a Patient with Polygonum multiflorum Thunb-Induced HepatitisHerbal Medicines – Acanthaceae – ZygophyllaceaeAcute Hepatitis Associated With the Use of an Herbal Supplement (Polygonum Multiflorum) Mimicking Iron-overload SyndromeHepatotoxic slimming aids and other herbal hepatotoxinsHerbal HepatotoxicityAcute Hepatitis Due to Shen-MinPolygonaceaeRecurrent Toxic Hepatitis in a Caucasian Girl Related to the Use of Shou-Wu-Pian, a Chinese Herbal PreparationSafety Issues Associated with Herbal Ingredients 6 April 2004Volume 140, Issue 7Page: W-30KeywordsHepatitis ALiverPregnancyProstatitisRNAResearch laboratoriesSerum glutamic oxaloacetic transaminaseThin layer chromatographyUltrasound imagingUrine ePublished: 6 April 2004 Issue Published: 6 April 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...