Case report reveals concurrent neuroectodermal tumor and nephroblastoma within a primary testicular mixed germ cell tumor, highlighting rare somatic-type malignancy transformations.
Key Points
To report a unique presentation of concurrent embryonic-type neuroectodermal tumor and nephroblastoma arising within a primary testicular mixed germ cell tumor.
Histopathologic and immunohistochemical evaluation of an orchiectomy specimen from a 36-year-old male with a 4.5 cm testicular mass (pT1).
Assessment of diagnostic markers including SOX11, synaptophysin, CD99, PAX8, and WT1, alongside clinical monitoring over 13 months.
Immunohistochemistry demonstrated diffuse SOX11 positivity in the neuroectodermal tumor and positive PAX8 and WT1 staining in the nephroblastoma component.
The patient developed retroperitoneal lymph node metastasis at 1 month post-orchiectomy, received chemotherapy, and remained free of metastatic disease at 13 months.