Clinical Use of a New Diagnostic Agent, Methopyrapone (Su-4885), in Pituitary and Adrenocortical Disorders

Article1 February 1961CLINICAL USE OF A NEW DIAGNOSTIC AGENT, METHOPYRAPONE (SU-4885), IN PITUITARY AND ADRENOCORTICAL DISORDERSE. M. GOLD, M.D., J. R. KENT, M.D., P. H. FORSHAM, M.D.E. M. GOLD, M.D.Search for more papers by this author, J. R. KENT, M.D.Search for more papers by this author, P. H. FORSHAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-2-175 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDisorders involving the adrenocortical secretion of cortisol have become more precisely characterized within recent years as knowledge concerning pituitary-adrenal physiology has increased and as newer, more critical means of study have become available. The secretion of cortisol by the adrenal cortex is normally regulated by corticotropin discharged from the anterior pituitary gland in response to stimuli from the ventral hypothalamus.1A quantitative estimate of the adrenal component of this system became possible when various procedures employing corticotropin as a direct and specific stimulator of the adrenal cortices were developed.2, 3For qualitatively demonstrating the extent of adrenocortical regulation by corticotropin,...Bibliography1. Harris GW: Neural control of the pituitary gland. Arnold, London, 1955. Google Scholar2. RenoldJenkinsForshamThorn AEDPHGW: The use of intravenous ACTH: a study in quantitative adrenocortical stimulation. J. Clin. Endocr. 12: 763, 1952. CrossrefMedlineGoogle Scholar3. GoldStarr EMP: Urinary excretion of 17-ketogenic steroids in normal subjects before and after stimulation with intramuscular zinc-ACTH. J. Clin Endocr. 19: 907, 1959. CrossrefGoogle Scholar4. 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Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication July 16, 1960.Presented in part at the Forty-first Annual Meeting of The American College of Physicians, San Francisco, California, April 4, 1960.†Part of the study was carried out under Grants C-3995 and MY-3951 from the National Institutes of Health.‡Assistant Professor of Medicine, School of Medicine, University of Southern California, Los Angeles; formerly Assistant Research Physician, Metabolic Unit, University of California School of Medicine, San Francisco, California.§Trainee, National Institute for Arthritis and Metabolic Diseases, and Research Fellow, Metabolic Unit and Department of Medicine, University of California School of Medicine, San Francisco.∥Professor of Medicine and Pediatrics, Director of the Metabolic Unit for Research in Arthritis and Allied Diseases, University of California School of Medicine, San Francisco.Requests for reprints should be addressed to P. 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