Why the study?
Does indomethacin improve postural hypotension in patients with chronic autonomic failure?
Population
4 patients with chronic autonomic failure and postural hypotension
Comparison
Indomethacin vs Baseline (before indomethacin treatment)
Design
Case_series
Authors
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Does not support indomethacin for postural hypotension; leaves open whether pressor sensitivity gains yield clinical benefit in autonomic failure.
Does indomethacin improve postural hypotension in patients with chronic autonomic failure?
Indomethacin is ineffective for treating postural hypotension in chronic autonomic failure, despite increasing pressor sensitivity to noradrenaline and angiotensin II.
Davies et al. (1980) studied this question.
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