Wrinkles induced in hairless mice with UVB radiation were treated with Zyderm and Zyplast injectable collagen implants. Image analysis of latex casts taken before and after implantation showed that wrinkle effacement was maintained during the 2–4-week period of the experiment. Histological examination of biopsies of implant sites demonstrated collagen implants that were well colonized by fibroblasts yet were quite free of inflammatory infiltrates. These findings suggest that the injectable collagen implants were well tolerated by the photodamaged skin.
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Kligman et al. (1993) studied this question.
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