Tomographic radiopharmaceutical imaging, or emission computed tomography (ECT), provides in vivo three-dimensional maps of a pharmaceutical labeled with a gamma-ray-emitting radionuclide. ECT has developed in two complimentary directions based on the type of radionuclide that is used. Positron emission computed tomography (PET) detects the two coincident 511-keV annihilation photos from position emitters such as /sup 11/C, /sup 13/N, /sup 15/O, and /sup 18/F. Single-photon-emission computed tomography (SPECT) involves detection of gamma rays emitted singly, and sequentially, by the radionuclide tracer. The author presents examples of PET and SPECT imaging devices and reviews a widely used reconstruction algorithm. Current research areas that are under active investigation are also described.>
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R.J. Jasczak (1988) studied this question.
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