Key result
In 981 Chinese patients hospitalized with major depressive disorder, 10.3% exhibited anxious depression, which was significantly associated with female sex, higher symptom severity, and elevated TSH.
Why the study?
Anxious depression is a common subtype of major depressive disorder with negative impacts on prognosis, motivating investigation into its frequency and influencing factors during first hospitalization in Chinese patients.
Cross-Sectional (n=981)
No
In Chinese patients hospitalized for major depressive disorder, anxious depression is present in 10.3% and is associated with higher symptom severity and specific metabolic parameters like TSH and BMI.
Identifies high AUD prevalence and risk factors in first-admitted Chinese MDD patients; leaves open causal links and broader applicability.
Background: Anxious depression (AUD) is a common subtype of major depressive disorder (MDD) and has a significant negative impact on disease progression and patient prognosis. Our study aimed to determine the frequency of AUD in Chinese patients with MDD during their first hospitalization and to identify factors that may influence the emergence and intensity of these AUD. Methods: This study enrolled 981 Chinese MDD patients on their inaugural hospital admission. Data on demographic details, clinical profiles, and psychological symptoms-such as depression, anxiety, psychosis, and illness severity scores-were gathered and examined. Results: The study found that 10.30% of the target population exhibited AUD. Compared with the non-AUD group, the AUD group had higher scores on Hamilton Depression Scale (HAMD), Positive symptom subscale of the Positive and Negative Symptom Scale (PSS), and Clinical Global Impression Scale - Severity of Illness (CGI-SI) and higher levels of fasting blood glucose (FBG), total cholesterol (TC), body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP). In addition, higher scores of HAMD, PSS and CGI-SI were risk factors for increasing the severity of anxiety, higher TC level was contrary. Conclusion: This study reveals the prevalence of AUD in hospitalized patients with MDD and identifies clinical factors that contribute to the onset and progression of AUD. Reporting these clinical features may help establish potential markers for early recognition and intervention.
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Zhu et al. (2024) conducted a cross-sectional in Major Depressive Disorder (n=981). Major Depressive Disorder was evaluated on Prevalence of anxious depression (AUD). In 981 Chinese patients hospitalized with major depressive disorder, 10.3% exhibited anxious depression, which was significantly associated with female sex, higher symptom severity, and elevated TSH.
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