Key result
Target-controlled infusion for remifentanil during carotid surgery significantly reduced intraoperative hypotension (26.1% vs 69.6%, P<0.001) and remifentanil requirement compared to continuous infusion.
Why the study?
Does target-controlled infusion of remifentanil improve hemodynamics and decrease remifentanil requirement compared to continuous IV weight-adjusted infusion in patients undergoing carotid surgery?
RCT (n=46)
randomized
Does target-controlled infusion of remifentanil improve hemodynamics and decrease remifentanil requirement compared to continuous IV weight-adjusted infusion in patients undergoing carotid surgery?
Absolute Event Rate: 26.1% vs 69.6%
p-value: p=<0.001
Target-controlled infusion of remifentanil during carotid endarterectomy improves hemodynamic stability and reduces total opioid requirement compared to continuous weight-adjusted infusion.
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May reduce hypotension in carotid surgery; confirms advantage of target-controlled over continuous remifentanil infusion.
Castro et al. (2003) conducted an RCT in carotid surgery (n=46). Target-controlled infusion (TCI) for remifentanil vs. Continuous IV weight-adjusted infusion of remifentanil (RIVA) was evaluated on Episodes of intraoperative hypotension (p=<0.001). Target-controlled infusion for remifentanil during carotid surgery significantly reduced intraoperative hypotension (26.1% vs 69.6%, P<0.001) and remifentanil requirement compared to continuous infusion.
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