Key result
Hyperuricemia was associated with an 83% increased risk of atrial fibrillation (RR 1.83), and gout was associated with a 33% increased risk (RR 1.33).
Why the study?
Although hyperuricemia and gout have been suggested to predict future risk of atrial fibrillation, epidemiological evidence remained lacking.
Does hyperuricemia or gout increase the incidence of atrial fibrillation in adults?
Meta-Analysis
Does hyperuricemia or gout increase the incidence of atrial fibrillation in adults?
This updated meta-analysis demonstrates that both hyperuricemia and gout are associated with a significantly increased risk of developing atrial fibrillation.
Background: Although it has been suggested that hyperuricemia and gout are predictive of the future risk of atrial fibrillation, there is still a lack of epidemiological evidence. Objective: Through an updated systematic review and meta-analysis, we aimed to assess the association between hyperuricemia/gout and atrial fibrillation. Methods: We performed a systematic search of EMBASE, PubMed, and Web of Science from their establishment to September 2021 for all relevant studies of hyperuricemia or gout and atrial fibrillation. Meta-analysis was conducted using the random-effects method to calculate the overall relative risk (RR) and 95% confidence intervals (CI), and subgroup analyses were performed on data subsets by geographic location and study design. Result: A total of 12 studies were included in this study. The results from 8 studies showed that hyperuricemia was associated with an increased incidence of atrial fibrillation (RR: 1.83, 95% CI: 1.35-2.47), but significant association was only observed in studies in China (RR: 1.88, 95% CI: 1.31-2.71) and cross-sectional studies (RR: 2.35, 95% CI: 1.97-2.81) rather than studies in Japan (RR: 1.74, 95% CI: 0.71-4.23) and cohort studies (RR: 1.20, 95% CI: 0.99-1.46). The results from 4 studies showed that gout was also associated with an increased risk of AF (RR: 1.33, 95% CI: 1.04-1.71). Conclusions: Hyperuricemia and gout are associated with an increased incidence of atrial fibrillation.
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Deng et al. (2022) conducted a meta-analysis in Atrial Fibrillation. Hyperuricemia vs. Without hyperuricemia was evaluated on Incidence of atrial fibrillation (RR 1.83, 95% CI 1.35-2.47). Hyperuricemia was associated with an 83% increased risk of atrial fibrillation (RR 1.83), and gout was associated with a 33% increased risk (RR 1.33).
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