Why the study?
Is there a relationship between total cholesterol, HDL, their ratio, and cerebral CO2 reactivity in elderly participants?
Is there a relationship between total cholesterol, HDL, their ratio, and cerebral CO2 reactivity in elderly participants?
Blood lipids, specifically HDL and the total cholesterol/HDL ratio, are significantly associated with cerebral CO2 reactivity, suggesting an effect on smaller cerebral blood vessels.
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HDL associations with cerebral vasoreactivity in the elderly are hypothesis-generating; prospective trials needed before clinical consideration.
Cholesterol and its subfractions play a role in the development of atherosclerosis. Cerebral CO2 reactivity reflects the compensatory capacity of cerebral arterioles. The authors investigated the relationship between total cholesterol, high-density lipoprotein (HDL), their ratio, and cerebral CO2 reactivity in 826 participants from the Rotterdam Study. Cerebral CO2 reactivity increased significantly with increasing levels of HDL and decreased significantly with an increasing total cholesterol/HDL ratio. This suggests that blood lipids may also affect smaller cerebral blood vessels.
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Bakker et al. (2000) studied this question.
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