September 1, 1996Alcoholism Clinical and Experimental Research

Ethanol and Cocaine Cause Additive Inhibitory Effects on the Calcium Transients and Contraction in Single Cardiomyocytes

View Full Paper

Ask AI

Bookmark

Population

Single fura2-loaded cardiomyocytes

Comparison

Simultaneous exposure to ethanol and cocaine vs Exposure to ethanol alone or cocaine alone

Design

Preclinical

Authors

JNJosep M. NicolásDepartament de Salut EREmanuel RubinRutgers, The State University of New Jersey ATAndrew P. ThomasAstraZeneca (United Kingdom)

Discussion

Member takes

Implication

Concurrent cocaine-ethanol use may heighten myocardial depression risk; leaves open human translation beyond this animal model.

Structured PICO

Population

Single fura2-loaded cardiomyocytes

Intervention

Simultaneous exposure to ethanol (100 mM) and cocaine (50 microM)

Comparator

Exposure to ethanol alone (100 mM) or cocaine alone (50 microM)

Outcome

Ca2+ transient amplitude and peak contractionsurrogate

Simultaneous use of cocaine and ethanol causes additive inhibitory effects on myocardial contractility and calcium transients, contributing to their combined cardiotoxicity.

Cite This Study

Nicolás et al. (1996) studied this question.

synapsesocial.com/papers/6a86c92e642e926077153dd1 https://doi.org/10.1111/j.1530-0277.1996.tb01949.x

View Full Paper

Ask AI

Bookmark

Ethanol and Cocaine Cause Additive Inhibitory Effects on the Calcium Transients and Contraction in Single Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ethanol and Cocaine Cause Additive Inhibitory Effects on the Calcium Transients and Contraction in Single Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider