An expeditious route to nitriles via dehydration of primary amides using halotriphenoxy phosphonium halides (TPPX2, X = Cl or Br) is described. The reaction proceeds under very mild conditions and allows the preparation of aromatic and aliphatic nitriles in good to excellent yields.
No takes yet. Share an insight, caveat, or question.
Vaccari et al. (2007) studied this question.