Key result
The rs320 and rs285 polymorphisms in the lipoprotein lipase gene were significantly associated with a decreased risk of stroke, with the rs320 G allele reducing risk compared to the T allele (OR 0.64).
Why the study?
Do LPL gene polymorphisms rs320 and rs285 reduce the risk of stroke in Asian populations?
Meta-Analysis (n=2,292)
Do LPL gene polymorphisms rs320 and rs285 reduce the risk of stroke in Asian populations?
Odds Ratio: 0.64 (95% CI 0.54–0.76)
p-value: p=<0.001
The LPL gene polymorphisms rs320 and rs285 are associated with a decreased risk of stroke in Asian populations, supported by computational evidence of altered RNA structure.
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May aid stroke risk prediction in Asians; extends genetic associations but should not yet change practice.
Nejati et al. (2018) conducted a meta-analysis in Stroke (n=2,292). LPL gene rs320 (HindIII) and rs285 (PvuII) polymorphisms vs. Wild-type/reference genotypes (e.g., T allele for rs320) was evaluated on Risk of stroke (rs320 G vs. T allele) (OR 0.64, 95% CI 0.54-0.76, p=<0.001). The rs320 and rs285 polymorphisms in the lipoprotein lipase gene were significantly associated with a decreased risk of stroke, with the rs320 G allele reducing risk compared to the T allele (OR 0.64).