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The author poses unanswered questions about vaccination, focusing on antigenic variation and epitope structure.
I pondered for several months over what I should write for this 100th Volume of FEMS Microbiology Letters before deciding that it might be useful to pose some questions about vaccination for which there seem to be no adequate answers. Although I have put these questions verbally to colleagues over several years, I thought that by putting the same questions in writing, it would not only help to clarify my own thoughts, but it might even bring some answers. To avoid accusations that I may have become too philosophical and impractical, I have also focussed on one of these problems, namely antigenic variation, which I think could be overcome within the foreseeable future as we learn more about the structure of epitopes which evoke protective immune responses.
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F. Brown (1992) studied this question.
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