Key result
A theoretical model of skeletal muscle contraction based on Newtonian mechanics and stochastic processes predicts the four transient phases following a length or force step.
A theoretical model based on Newtonian mechanics, entropic springs, and stochastic processes predicts the transient phases of skeletal muscle fiber shortening.
No immediate clinical impact; leaves open whether the model extends to cardiac muscle or guides future experiments.
The model analyzes the muscle fiber as a deformable system for which experimental data are determinated with the help of the laws of Newtonian mechanic. The model predicts the four transient phases for the shortening of a muscle fiber according to a force or length step. The model shows, on the one hand, the importance of the viscosity during the first phase of these two types of step and, secondly, the interdependence of the six other phases towards a bimodal state after disappearance of actions due to viscosity. The model provides an interpretation for the behavior of a fiber with shortening staircase. The model is consistent with experimental data during temperature changes or various structural alterations.
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Sylvain Louvet (2013) studied Skeletal muscle contraction. Theoretical model of skeletal muscular contraction was evaluated. A theoretical model of skeletal muscle contraction based on Newtonian mechanics and stochastic processes predicts the four transient phases following a length or force step.
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