Key result
Introduction of Myosin S2 into intact rat ventricular myocytes increased contractility by approximately 30% and lengthened contraction and relaxation times without affecting [Ca2+]i transient amplitude.
Why the study?
Does the introduction of Myosin S2 alter contractility and intracellular Ca2+ in intact rat ventricular myocytes?
Population
Rat ventricular myocytes reversibly permeabilised with the pore-forming toxin streptolysin O
Design
Preclinical
Authors
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Should not change practice; leaves open whether Myosin S2 modulates myofilament Ca2+ sensitivity in humans.
Does the introduction of Myosin S2 alter contractility and intracellular Ca2+ in intact rat ventricular myocytes?
Introduction of Myosin S2 into intact rat ventricular myocytes increases contractility without affecting intracellular Ca2+ transient amplitude, suggesting C-protein regulates contraction via myofilament Ca2+ sensitivity.
Calaghan et al. (2000) studied this question. Introduction of Myosin S2 was evaluated on Contractility, time to peak of contraction, time to half-relaxation, and [Ca2+]i transient amplitude. Introduction of Myosin S2 into intact rat ventricular myocytes increased contractility by approximately 30% and lengthened contraction and relaxation times without affecting [Ca2+]i transient amplitude.
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