Quinacrine (0.15 mM), when added to the postirradiation incubation medium of E. coli K-12 rec+ cells, markedly potentiated the killing induced by x-irradiation. Alkaline sucrose gradient studies showed that quinacrine was a potent inhibitor of the repair of DNA single-chain breaks in rec+ cells and that this inhibition was largely irreversible. The recA13 mutant (deficient in the slow repair of x-ray induced single-chain breaks in DNA) did not show radiation sensitization by quinacrine. The possible use of quinacrine as a radiation potentiator in humans is discussed.
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Fuks et al. (1971) studied this question.
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