Key result
In a porcine model, an AVI-4126-eluting PC stent significantly reduced neointimal area compared with control (2.3 vs. 3.9 mm2; P=0.0077) and allowed complete reendothelialization.
Why the study?
Does an AVI-4126-eluting PC stent reduce neointimal formation and improve vascular healing in a porcine coronary restenosis model?
Population
9 pigs in a porcine coronary restenosis model
Comparison
AVI-4126-eluting phosphorylcholine-coated stent vs Control stent
Design
Preclinical
Follow-up
2 to 6 hours and 28 days
Authors
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AVI-4126-eluting stents merit human trials for restenosis; leaves open translation beyond porcine models.
Does an AVI-4126-eluting PC stent reduce neointimal formation and improve vascular healing in a porcine coronary restenosis model?
Absolute Event Rate: 2.3% vs 3.9%
p-value: p=0.0077
An AVI-4126-eluting stent successfully inhibited c-myc expression and reduced neointimal hyperplasia by 40% without impairing endothelialization in a porcine model.
Kipshidze et al. (2004) studied Coronary restenosis (n=9). AVI-4126-eluting phosphorylcholine-coated (PC) stent vs. Control was evaluated on Neointimal area (p=0.0077). In a porcine model, an AVI-4126-eluting PC stent significantly reduced neointimal area compared with control (2.3 vs. 3.9 mm2; P=0.0077) and allowed complete reendothelialization.