Key result
Bromocriptine treatment for ablactation induced coronary spasm and acute coronary syndrome, which subsequently triggered Takotsubo syndrome in a 37-year-old woman.
Case Report (n=1)
This case report highlights that bromocriptine-induced coronary spasm can cause acute coronary syndrome, which may serve as a trigger for Takotsubo syndrome.
May warrant caution with bromocriptine for ablactation; single case leaves open causal role in Takotsubo syndrome.
Bromocriptine-induced coronary spasm (BICS) causing myocardial infarction has been reported. Association between BICS and Takotsubo syndrome (TS) has not been described. We report on a 37-year-old woman presenting with a clinical picture of acute coronary syndrome 1 day after initiation of treatment with bromocriptine for ablactation 3 weeks after a full-term spontaneous vaginal delivery. Coronary angiography showed diffuse narrowing of a large diagonal branch. Left ventriculography showed widespread hypokinesia extending beyond the diagonal branch supply region. There was a slight elevation of myocardial infarction biomarkers that was disproportional to the degree of left ventricular dysfunction. Follow-up coronary angiography, intravascular ultrasound and left ventriculography showed normal coronary arteries including the diagonal branch and complete normalization of the left ventricular function. Cardiac magnetic resonance examination showed no signs of late myocardial gadolinium enhancement. The clinical picture and course of the disease was consistent with TS. Consequently, we describe for the first time a case of TS triggered by myocardial ischemia caused by BICS. Furthermore, our case and sufficient supporting data from the literature demonstrate that acute coronary syndrome is an important and frequent but up till now missed trigger factor for TS.
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Y‐Hassan et al. (2011) conducted a case report in Bromocriptine-induced coronary spasm and Takotsubo syndrome (n=1). Bromocriptine was evaluated. Bromocriptine treatment for ablactation induced coronary spasm and acute coronary syndrome, which subsequently triggered Takotsubo syndrome in a 37-year-old woman.
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