Several kinds of modified guanidines were applied to the trimethylsilylcyanation of 3‐phenylpropanal, cylohexanecarboxaldehyde, pivalaldehyde, and 4‐phenyl‐2‐butanone. Good to moderate enantioselectivity was obtained, even on a ketonic substrate, when a C 2 ‐symmetrical bicyclic guanidine, (2 S ,3 S ,7 S ,8 S )‐tetraphenyl‐1,4,8‐triaza[2.2.0]bicyclooct‐4‐ene, was used as a base catalyst.
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Kitani et al. (2005) studied this question.
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