A scalable process for the preparation of high purity dimethyl 1,4-cubanedicarboxylate ( 3 ) is reported. The work described herein builds on previous synthetic work from this and other laboratories, to provide a reliable process that can be used to prepare multigram quantities of 3 in a partially telescoped, 8 step process, with minimal purification of intermediates.
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Falkiner et al. (2013) studied this question.
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