Key result
C-reactive protein showed poor diagnostic performance for screening acute coronary syndromes in low-risk outpatients, with an AUC of 0.61 and a pooled diagnostic OR of 1.81 (95% CI 1.06-3.07).
Why the study?
Do new protein markers accurately diagnose acute coronary syndromes in low-risk symptomatic outpatients in the emergency department?
Population
Symptomatic outpatients at low risk of acute coronary syndromes and related complications, comparable to…
Design
Systematic_review
Authors
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Does not support CRP for ACS screening in low-risk outpatients; reinforces limited diagnostic value of protein markers in this setting.
Systematic Review
Do new protein markers accurately diagnose acute coronary syndromes in low-risk symptomatic outpatients in the emergency department?
Odds Ratio: 1.81 (95% CI 1.06–3.07)
Published evidence does not support the routine use of new protein markers, including C-reactive protein, for screening low-risk outpatients for ACS in the emergency department.
Mitchell et al. (2005) conducted a systematic review in Acute coronary syndromes. New protein markers (C-reactive protein) was evaluated on Diagnostic accuracy for acute coronary syndromes (diagnostic OR 1.81, 95% CI 1.06-3.07). C-reactive protein showed poor diagnostic performance for screening acute coronary syndromes in low-risk outpatients, with an AUC of 0.61 and a pooled diagnostic OR of 1.81 (95% CI 1.06-3.07).
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