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Silver nanocrystals (Ag NCs) hold promising antibiotic and antiviral properties in biological systems. The biodistribution of silvernanostructures injected into animals in vivo is currently unknown, remaining as a fundamental issue for potential therapeutic applications. Here, we injected Ag NCs capped with bovine serum albumin (BSA) in live rats to elucidate their fate in several organs including liver, heart and brain. Very significant accumulations of nanoparticles were confirmed by inductively coupled plasma mass spectroscopy (ICPMS) and transmission electron microscopy (TEM) techniques on the liver and heart. In contrast, the brain tissue did not reveal evidence of particles content. Our results suggest that Ag+ permeated across the blood–brain barrier (BBB), and followed swift clearance from the organ. We investigated the kinetic biodistribution of silver nanoparticles (Ag NPs) on adult rats. Slow excretion and clearance of Ag NPs from rats via renal pathway was confirmed.
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Garza‐Ocañas et al. (2009) studied this question.
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