Target‐Selective Photodegradation of HIV‐1 Protease and Inhibition of HIV‐1 Replication in Living Cells by Designed Fullerene–Sugar Hybrids

Sweet degradation: A designed fullerene–sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.