Therapeutic measurements to control hepatitis C reinfection after orthotopic liver transplantation (OLT) still pose many problems and remain unsatisfactory [1]. While hepatitis C viremia decreases strongly during the anhepatic phase of OLT, initiation of viral replication does occur within hours or days [2,3]. At this early stage after OLT, i.e. once chronic HCV reinfection is established, the virologic response is often markedly reduced. Although specifically targeted antiviral therapeutic regimes for hepatitis C (STAT-C) are currently extensively studied, none of them have been tried in the post-OLT period treatment.
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Neumann et al. (2010) studied this question.
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