Summary.— The outermost part of the epidermis, including part of the pilo‐sebaceous apparatus, has been sampled, using a cyanoacryalnte adhesive, in patients with acne of varying severity, controls, and in acne patients treated with long term tetracycline. At the site sampled (left upper hack) patients with acne have an increased amount of inspissated material as compared with controls; this appears increased in relation to the severity of the acne. The inspissated material, which is partly keratin and partly lipid, could possibly obstruct the outflow of sebum from the duct.
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Holmes et al. (1972) studied this question.
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