Key result
Pediatric platelets demonstrated lower granular release than adults' platelets, including a 1.2-fold lower alpha- and 1.1-fold lower dense granule release after CRP+SFLLRN stimulation.
Why the study?
Studies on platelet function in children past the neonatal period are sparse and controversial, with conflicting reports on whether pediatric platelets are more or less active than adult platelets.
Are pediatric platelets more or less reactive compared to adult platelets?
Cross-Sectional (n=125)
Are pediatric platelets more or less reactive compared to adult platelets?
Healthy pediatric platelets exhibit moderately lower granular release compared to adults, which may have implications for understanding pediatric hemostasis and thrombosis.
Pediatric platelet hyporeactivity warrants age-specific reference ranges in testing; leaves open maturation timeline for prospective confirmation.
Studies on platelet function in children older than neonatal period are few and their results are controversial. The pediatric platelets were alternatively reported to be more active or less active than adults' ones. We compared platelet function in the several age groups of children to adults and evaluated the age when platelet function reaches the adults' status. The study included 76 healthy children and 49 healthy adult volunteers. Types of platelet activation used included: collagen-related peptide (CRP) and PAR-1 activating peptide SFLLRN; SFLLRN, PAR-4 activating peptide AYPGKF and adenosine diphosphate (ADP); ADP. The parameters determined included forward (FSC) and side scatter (SSC), CD42b, CD61, CD62P, PAC-1, annexin V binding and mepacrine release levels. Resting pediatric platelets were similar to adults' platelets except for 1.2-fold decreased FSC and dense granules volume in youngest children, and 2.5-fold increased annexin V level in children aged 1-10 years. After CRP+SFLLRN stimulation, pediatric platelets had a 1.2-fold lower alpha- and 1.1-fold lower dense granule release than adults. For SFLLRN+AYPGKF+ADP stimulation, this was observed only for youngest children. The response to ADP stimulation was identical for pediatric platelets and adults. Pediatric platelets have lower granular release than adults' platelets, which persists until the age of 18.
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Ponomarenko et al. (2021) conducted a cross-sectional in Healthy (n=125). Pediatric age (children) vs. Adults was evaluated on Platelet function and activation parameters (including granular release, FSC, SSC, CD42b, CD61, CD62P, PAC-1, annexin V binding, and mepacrine release). Pediatric platelets demonstrated lower granular release than adults' platelets, including a 1.2-fold lower alpha- and 1.1-fold lower dense granule release after CRP+SFLLRN stimulation.
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