Key result
Fentanyl as an adjuvant to bupivacaine in ultrasound-guided transversus abdominis plane block significantly prolonged the time to first analgesic (537.09 vs 398.73 minutes) compared to bupivacaine alone following abdominal hysterectomy.
Why the study?
Does fentanyl as an adjuvant to bupivacaine in ultrasound-guided TAP block improve the duration and quality of postoperative analgesia in patients undergoing abdominal hysterectomy?
Does fentanyl as an adjuvant to bupivacaine in ultrasound-guided TAP block improve the duration and quality of postoperative analgesia in patients undergoing abdominal hysterectomy?
Absolute Event Rate: 537.09% vs 398.73%
p-value: p=<0.001
The addition of fentanyl to bupivacaine in ultrasound-guided TAP block significantly prolongs the duration and improves the quality of postoperative analgesia following abdominal hysterectomy without major adverse effects.
May extend post-hysterectomy analgesia via fentanyl-adjuvanted TAP block; hypothesis-generating and requires larger RCTs before practice change.
The transversus abdominis plane (TAP) block is a regional analgesia technique that forms part of the multimodal approach to postoperative pain management for abdominal surgeries. Local anaesthetics like Bupivacaine with longer duration are preferred for TAP block. However, even that is insufficient to match the duration of postoperative pain in abdominal surgeries. The current study was to evaluate if Fentanyl as an adjuvant to bupivacaine in ultrasound guided TAP block improves the duration and quality of postoperative analgesia following abdominal hysterectomy.
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Rajasekhar et al. (2019) studied Postoperative pain following abdominal hysterectomy (n=44). Fentanyl as an adjuvant to bupivacaine vs. 19.5 ml of bupivacaine hydrochloride 0.25% + 0.5 ml saline 0.9% was evaluated on Time to First Analgesic (TFA) in minutes (p=<0.001). Fentanyl as an adjuvant to bupivacaine in ultrasound-guided transversus abdominis plane block significantly prolonged the time to first analgesic (537.09 vs 398.73 minutes) compared to bupivacaine alone following abdominal hysterectomy.
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