Key result
Thiamine pre-treatment attenuated doxorubicin-induced reductions in cardiac function, preserving fractional shortening at 46.7% compared to 38.2% with doxorubicin alone, while reducing oxidative stress and apoptosis.
Why the study?
Mechanisms of doxorubicin-induced cardiotoxicity are not fully elucidated, and because thiamine deficiency is linked to myocardial dysfunction and cardiomyopathy, investigators examined whether thiamine provides cardioprotection against doxorubicin-mediated cardiotoxicity.
Does thiamine pretreatment prevent doxorubicin-induced cardiotoxicity in rats?
Population
48 Wistar albino rats
Comparison
Thiamine vs no treatment in healthy and doxorubicin-treated rats
Design
Preclinical animal study
Authors
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May attenuate DOX cardiotoxicity in rats via redox and apoptotic pathways; leaves open clinical translation to chemotherapy patients.
Does thiamine pretreatment prevent doxorubicin-induced cardiotoxicity in rats?
Absolute Event Rate: 46.7% vs 38.2%
Thiamine pre-treatment ameliorates doxorubicin-induced cardiotoxicity in rats by modulating oxidative stress, suppressing apoptosis, and preserving left ventricular ejection fraction.
Rankovic et al. (2021) studied Doxorubicin-induced cardiotoxicity (n=48). Thiamine vs. Doxorubicin alone was evaluated on Fractional shortening (referred to as ejection fraction in text). Thiamine pre-treatment attenuated doxorubicin-induced reductions in cardiac function, preserving fractional shortening at 46.7% compared to 38.2% with doxorubicin alone, while reducing oxidative stress and apoptosis.
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