Key result
Acute pretreatment with pravastatin and simvastatin significantly reduced infarct size to 10% and 27% respectively, compared to 42% in untreated control rat hearts subjected to ischemia/reperfusion.
Why the study?
Does acute pretreatment with simvastatin or pravastatin reduce myocardial stunning, arrhythmias, and lethal injury in isolated rat hearts subjected to ischemia/reperfusion?
Population
Isolated hearts from male Wistar rats subjected to 30-min global ischemia and reperfusion.
Comparison
Simvastatin or pravastatin given as components… vs Control untreated hearts perfused with perfusion…
Design
Preclinical
Follow-up
2-h reperfusion
Authors
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Should not yet change clinical practice; hypothesis-generating for acute statin cardioprotection in ischemia/reperfusion.
Does acute pretreatment with simvastatin or pravastatin reduce myocardial stunning, arrhythmias, and lethal injury in isolated rat hearts subjected to ischemia/reperfusion?
Absolute Event Rate: 10% vs 42%
p-value: p=<0.05
Differences in water solubility of statins may underlie their distinct cardioprotective effects on myocardial stunning and lethal injury induced by ischemia/reperfusion.
Čarnická et al. (2011) studied Myocardial ischemia/reperfusion injury (n=36). Simvastatin and Pravastatin vs. Perfusion medium only (Control) was evaluated on Infarct size (percentage of left ventricular area) (p=<0.05). Acute pretreatment with pravastatin and simvastatin significantly reduced infarct size to 10% and 27% respectively, compared to 42% in untreated control rat hearts subjected to ischemia/reperfusion.