Key result
The Thioredoxin Family Protein system plays a key role in regulating the cellular redox state and is a significant target in the physiopathology of perinatal asphyxia.
The Thioredoxin Family Protein system emerges as a potential key therapeutic target for mitigating the devastating consequences of perinatal asphyxia.
Caution against premature clinical adoption in perinatal asphyxia; leaves open thioredoxin modulation for targeted trials.
Hypoxia during birth is one of the leading childhood mortality worldwide and results in many neurodisabled survivors.Several lines of evidence demonstrated that reactive oxygen species are the final step in the metabolic disorders produced by a deficit of oxygen.However, any specific therapy has been effective to ameliorate the devastating consequences of perinatal asphyxia.In the last few years, the Thioredoxin Family Protein has emerged as a key player in the regulation of the redox state of the cells in normal and pathological conditions.This review summarizes new insight of the role of Trxs, Prxs and Grxs in physiopathology of perinatal asphyxia.
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A 2016 study conducted a review in Perinatal Asphyxia. Thioredoxin Family Protein (Trxs, Prxs, Grxs) was evaluated. The Thioredoxin Family Protein system plays a key role in regulating the cellular redox state and is a significant target in the physiopathology of perinatal asphyxia.
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