Highly Enantioselective Michael Addition of 2‐Fluoro‐1,3‐diketones to Nitroalkenes

Highly enantioselective Michael addition of 2‐fluoro‐1,3 diketones to nitroalkenes was developed, and the desired adducts were obtained in good chemical yields with moderate to good diastereoselectivties and excellent enantioselectivities. Subsequent stereoselective reduction of the carbonyl groups led to the preparation of a functionalized fluoroisostere of glycerol that contains four continuous stereogenic centers.