Cerebral Berry Aneurysms-Cromnpton MEDIBALlJURNALThe critical size-that is, the size beyond which aneurysms suddenly become unstable and likely to rupture-was a maxi- mum external diameter of 4 mm.Aneurysms can probably form or begin at any age and may enlarge and rupture rapidly.In patients with multiple aneurysms the largest aneurysm had ruptured in 88%.When combinations of middle cerebral and internal carotid aneurysms were present on the same side the proximal aneurysm was more often ruptured.Infiltration of the wall of the aneurysm with white blood cells and fibrin was thought to precede enlargement or rupture.This was thought to be due to endothelial damage as a result of pulsation, turbulent flow, or ischaemia resulting from mural thrombosis.
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M. L. Newhouse (1966) studied this question.
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