Key result
Positive thyroid autoantibodies (AMA and ATG) were significantly associated with higher disease activity (SLEDAI scores) (p < 0.01), as well as with lupus nephritis and vasculitis in patients with SLE.
Why the study?
Does thyroid antibody positivity correlate with disease activity in patients with systemic lupus erythematosus?
Cross-Sectional (n=100)
No
Does thyroid antibody positivity correlate with disease activity in patients with systemic lupus erythematosus?
Thyroid autoantibodies are highly prevalent in SLE patients and correlate significantly with disease activity (SLEDAI score), lupus nephritis, and vasculitis.
Answers are grounded in this paper and cite their sources.
Suggests thyroid autoantibodies may serve as biomarkers for severe SLE manifestations; leaves open whether routine screening.
SLE is the prototype of the autoimmune disease affecting predominantly women. It affects women in their reproductive years. An autoimmune thyroid disease marked by the presence of antibodies directed against thyroid antigens has been associated with SLE, GCA and Sjogren's syndrome. A number of studies have suggested that thyroid disease is more common in SLE. So SLE patients should be routinely investigated for Autoimmune Thyroid disease.
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Pillai et al. (2017) conducted a cross-sectional in Systemic Lupus Erythematosus (SLE) (n=100). Thyroid autoantibodies (AMA and ATG) vs. Negative thyroid autoantibodies was evaluated on Association between antimicrosomal antibody (AMA) positivity and SLEDAI score (p=<0.01). Positive thyroid autoantibodies (AMA and ATG) were significantly associated with higher disease activity (SLEDAI scores) (p < 0.01), as well as with lupus nephritis and vasculitis in patients with SLE.
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