Enantiomer separation has been often realized with reversed phase liquid chromatography using diastereomerizing reagents with simply-hydrophobized silica. The present study demonstrates that diastereomer selectivity can be enhanced through highly-oriented organic phase produced by achiral poly(octadecyl acrylate)-grafted on silica and a carbonyl-π interaction due to the acrylate moiety is effective as the driving force for the selectivity enhancement.
No takes yet. Share an insight, caveat, or question.
Ihara et al. (2000) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: