Benzimidazole-based Nurr1 agonists: Combinatorial chemistry and structure-based design were joined together to produce a lead-finding library of compounds focused on the nuclear receptor target family. A second-generation library directed against Nurr1, a specific orphan member of this family, was also prepared. This protocol allowed the discovery of a Nurr1 agonist with an EC50 value of 8 nM.
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Dubois et al. (2006) studied this question.
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