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The catalytic sites of ribozymes generally contain two or more metal ions. Guanine is the nucleobase most often involved in binding to metal ions. The repulsion between two M2+ ions simultaneously coordinated to guanine in aqueous solution was investigated by using complex 1 (see picture; dien=diethylenetriamine, R=C2H5) as a model, for which the stability constants for the binding of Mg2+ and Cu2+ were determined.
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Knobloch et al. (2004) studied this question.
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