We disclose a palladium and urea ligand-mediated heteroannulation of 2-bromophenols and 1,3-dienes. This method addresses synthetic challenges present in the palladium-catalyzed heteroannulation of bifunctional reagents and olefins by engaging a diverse scope of coupling partners under a unified set of reaction conditions. Our recently developed urea ligand platform outperforms phosphine ligands to generate the dihydrobenzofuran motif in a convergent manner.
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Houghtling et al. (2022) studied this question.
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