Quadranes, discovered with the isolation of (–)‐quadrone in 1978, are biologically active naturally occurring sesquiterpenes featuring a distinctive set of bi‐ to tetracyclic ring systems. The available data for this family of natural products, including isolation data, biosynthetic considerations, a comprehensive compilation of the reported biological activities, and an exhaustive survey of the synthetic work in this area so far, are critically analyzed.
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Presset et al. (2010) studied this question.
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