A highly selective asymmetric induction into symmetrical molecules having prochirality has been developed by utilizing 4 ( R ) - methoxycarbonyl-1,3-thiazolidine-2-thione.In the model experiments of total synthesis of viginiamycin MZ, the derivatives of 1.3-oxoazolidine-2-thione and 1,3-thiazolidine-2-thione were utilized effectively.
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Eiichi Fujita (1984) studied this question.