One-pot Synthesis of α-Alkoxy Azides from Carbonyl Compounds Catalyzed by Iron(III) Chloride

In the presence of alkoxytrimethylsilane and a catalytic amount of iron(III) chloride, the reaction of various carbonyl compounds with trimethylsilyl azide afforded the corresponding α-alkoxy azides. This reaction could be suitable especially for azidation of aromatic aldehydes and proceeds under mild conditions in a convenient one-pot manner.