July 30, 1982Science

Small Nuclear RNA U2 Is Base-Paired to Heterogeneous Nuclear RNA

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Population

Cultured human (HeLa) cells

Design

Preclinical

Authors

Discussion

No immediate clinical implications; leaves open U2 snRNA's role in human mRNA processing.

Population

Cultured human (HeLa) cells

Intervention

Treatment with a psoralen derivative to cross-link RNA chains

Outcome

Base-pairing of U2 RNA to heterogeneous nuclear RNAsurrogate

This basic science study demonstrates that U2 RNA is base-paired to heterogeneous nuclear RNA, suggesting a role in messenger RNA processing.

Calvet et al. (1982) studied this question.

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