Coculture of chick embryonic sympathetic neurones with spinal cord explants induced an age-dependent increase in the acetylcholine receptor numbers of the ganglion cells. These acetylcholine receptors did not appear to be necessary for the initial formation of spinal cord-ganglion synapses since their blockade with the alpha-bungarotoxin-horseradish peroxidase complex did not prevent synapse formation in culture. The presence of acetylcholine receptors appears to be sufficient for synapse formation since inappropriate motoneurone-ganglion synapses could form and were stable.
No takes yet. Share an insight, caveat, or question.
Leah et al. (1986) studied this question.