Clinical trial of fluid infusion rates for pediatric diabetic ketoacidosis

Neurological complications of diabetic ketoacidosis (DKA) are still causes of significant mortality and morbidity in type 1 diabetes (T1D). Children are still being reported with acute cerebral infarction (CI) and extra pontine myelinolysis (EPM) at onset of T1D (1). Frequently, their clinical management had not been optimal and putative risk factors for such complications had been neglected. Not only cerebral edema (CE), but also other severe neurological complications such as CI should be suspected when neurological deterioration occurs during DKA, and these may still cause brain injuries ranging from mild to severe (1).