Key result
Low-intensity resistance exercise with blood flow restriction and high-intensity exercise without restriction similarly resulted in non-significant changes in serum IL-6 and MMP-9 levels.
Why the study?
Blood flow restriction exercise is assumed to activate blood factors and stimulate arterial angiogenesis, but its effect alongside eccentric resistance training on IL6 and MMP9 levels needed evaluation.
Does low-intensity eccentric exercise with blood flow restriction affect serum IL6 and MMP9 levels compared to high-intensity eccentric exercise without blood flow restriction in active young men?
RCT (n=16)
randomly assigned
Does low-intensity eccentric exercise with blood flow restriction affect serum IL6 and MMP9 levels compared to high-intensity eccentric exercise without blood flow restriction in active young men?
Low-intensity resistance exercise with blood flow restriction and high-intensity resistance exercise without blood flow restriction have similar non-significant effects on IL6 and MMP9 serum levels in active young men.
Neither protocol altered IL-6 or MMP-9 acutely; hypothesis-generating for BFR angiogenesis effects, requiring larger randomized studies.
Background: It has been assumed that during and after BFR exercises, many blood factors are activated and angiogenesis response is stimulated in the arteries. Objectives: Therefore, the current study aimed to determine the effect of two eccentric resistance training methods with and without blood flow restriction on serum IL6 and MMP9 levels in active young men. Methods: In this quasi-experimental study, 16 healthy men with a mean age of 27.8 ± 2.85 (years), the weight of 79.4 ± 12.4 (kg), and a body mass index of 25.5 ± 3.7 (kg/m2) were randomly assigned to either low-intensity eccentric group with BFR or the high-intensity eccentric without BFR. The high-intensity (70% - 80% maximum voluntary contraction MVC) eccentric exercise without BFR included 3 - 5 cycles of eccentric contraction of the quadriceps muscles, up to exhaustion, whereas low-intensity eccentric exercise executed similar exercise modality at intensity of 20% - 30% MVC with blood flow restriction up to exhaustion. Blood samples were taken from antecubital both before and after the exercise to measure serum IL6 and MMP9 values using the ELISA method. Data were analyzed using paired t-test and analysis of variance with repeated measure test in SPSS version 22. A P value of < 0.05 was defined as statistically significant. Results: High-intensity resistance per se and low-intensity resistance exercise with BFR similarly resulted in a non-significant reduction of IL-6 and elevated levels of MMP-9 serum levels in active young men. Conclusions: Overall, the results indicated that a low-intensity resistance exercise session with restricted blood flow and a high-intensity resistance exercise without blood flow restriction equally did not affect IL6 and MMP9 serum of active young men. Further studies are needed to clarify the exact exercise modality that sufficiently stimulates angiogenesis.
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Eslamdoust et al. (2020) conducted an RCT in healthy active young men (n=16). Low-intensity eccentric exercise with blood flow restriction vs. High-intensity eccentric exercise without blood flow restriction was evaluated on Serum IL6 and MMP9 levels. Low-intensity resistance exercise with blood flow restriction and high-intensity exercise without restriction similarly resulted in non-significant changes in serum IL-6 and MMP-9 levels.
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