Key result
Expression of the transmembrane serine protease TMPRSS2 in Vero cells efficiently supported the cleavage of the human metapneumovirus F protein and enabled efficient viral multiplication.
Population
Vero cells and other cell lines infected with recombinant human metapneumovirus or influenza virus
Comparison
Constitutive expression of transmembrane serine… vs Cells not expressing TMPRSS2 or expressing…
Design
Preclinical
Authors
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TMPRSS2 may support HMPV entry in vitro; leaves open its role as a therapeutic target in human respiratory infections.
TMPRSS2 efficiently cleaves the HMPV F protein and supports viral multiplication, indicating it is a candidate host protease involved in HMPV respiratory tract infections.
Shirogane et al. (2008) studied Human metapneumovirus (HMPV) infection. TMPRSS2 expression vs. Wild-type Vero cells was evaluated on HMPV F protein cleavage and viral multiplication. Expression of the transmembrane serine protease TMPRSS2 in Vero cells efficiently supported the cleavage of the human metapneumovirus F protein and enabled efficient viral multiplication.
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