Key result
Aspirin for primary prevention in individuals without cardiovascular disease did not significantly reduce non-fatal stroke (OR 0.94; 95% CI 0.85-1.04) but increased hemorrhagic stroke risk.
Why the study?
The benefits of aspirin for primary prevention of stroke are uncertain.
Does aspirin prevent stroke in individuals without cardiovascular disease?
Meta-Analysis (n=157,054)
Does aspirin prevent stroke in individuals without cardiovascular disease?
Aspirin provides no net clinical benefit for primary stroke prevention in patients without cardiovascular disease, as it fails to significantly reduce non-fatal stroke while increasing the risk of hemorrhagic stroke and major gastrointestinal bleeding.
Answers are grounded in this paper and cite their sources.
No benefit for primary stroke prevention; challenges routine aspirin use and reinforces guideline recommendations against it in low-risk adults.
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Judge et al. (2019) conducted a meta-analysis in Without cardiovascular disease (n=157,054). Aspirin was evaluated on non-fatal stroke (OR 0.94, 95% CI 0.85 to 1.04). Aspirin for primary prevention in individuals without cardiovascular disease did not significantly reduce non-fatal stroke (OR 0.94; 95% CI 0.85-1.04) but increased hemorrhagic stroke risk.
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